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Oral products: peak level after 20-30 minutes, bioavailability ~40% (a significant fraction is swallowed, absorbed via the gastrointestinal tract, and subject to first-pass metabolism)
Increased carbon dioxide levels: Smoking affects the gas exchange process in your lungs, resulting in higher levels of carbon dioxide in your bloodstream
[See drug paraphernalia.] hophead A user of cannabis [36] hot box Slang term for smoking cannabis in a closed space
Martinez D, Narendran R, Foltin RW, Slifstein M, Hwang DR, Broft A, Huang Y, Cooper TB, Fischman MW, Kleber HD, Laruelle M (2007) Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
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