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Further, the reduction in viability after LDHB silencing was not significantly augmented by additional FSP1 knockout (sgFSP1) (Supplementary Fig

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Targeting mitochondrial enzymes is also promising

So I think theres a concern here that, if you start prescribing this, for addiction that there will be a point in which when theyre no longer on the a, the medications that their cravings for cocaine or alcohol or heroin, you name it will return and thats a concern because if you have stopped using a substance as powerful as heroin for a period of time and then you end up going back to it, then your tolerance is much reduced and your risk of overdose is much, much higher

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