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Given the increase in physical activity levels by the participants, the energy intake may have also increased, which could have resulted in changes in the dietary macronutrient composition

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Studies on the gut microbiome have identified distinct genera of bacteria capable of synthesizing thiamine, including Lactobacillus , Bifidobacterium , Escherichia coli , Enterococcus , and Clostridium (55, 56)

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In the real world, it generally involves using doses lower than the established therapeutic amount needed to achieve the intended medical benefit