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Glyoxalase 1 and protein kinase C as potential therapeutic targets for latestage breast cancer

Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism

It selectively hydrolyzes GSH, producing Cys-Gly and 5-oxoproline (a cyclized form of glutamate) (11,51), thereby accelerating formation of the cellular oxidative environment

Cold-chain integrity is maintained in-state without the risks of long-distance shipping

Atopic dermatitis and nitrosative stress The role of RNS in the pathogenesis of skin allergies has been examined less extensively than in bronchial asthma (159), Kubo et al