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In the liver and skeletal muscle, elevated FFAs and the accumulation of lipid intermediates such as diacylglycerol can also activate signaling molecules including protein kinase C, which further suppresses insulin signaling (155)

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Del Prato S, Kahn SE, Pavo I, Weerakkody GJ, Yang Z, Doupis J, Aizenberg D, Wynne AG, Riesmeyer JS, Heine RJ et al (2021) Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial

Wegovy (semaglutide) is a GLP-1 receptor agonist that slows gastric emptying, potentially exacerbating pre-existing gastric conditions Common gastrointestinal side effects include nausea (44%), vomiting (24%), dyspepsia, abdominal pain, and constipation Gastritis is not listed as a recognised adverse effect in the UK Summary of Product Characteristics Patients with severe gastrointestinal disease or history of peptic ulcer disease should discuss risks with their prescriber before starting treatment Seek urgent medical advice for severe abdominal pain, vomiting blood, black stools, or persistent symptoms that do not improve Table of Contents Can Wegovy Cause Gastritis

Omaha Semaglutide (and medications like it) can lead to approximately a 15% decrease in body weight