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As indicated, the inhibition of the plasma membrane L-type Ca 2+ channels results in reduced intracellular Ca 2+ concentration and a consequent reduction in the contractile activity of smooth muscle

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On the other hand, overexpression of Nrf2 (transcriptional regulator of seleno-GPxs) contributed to the increase in the radioresistance and stemness in glioma stem cells (GSCs) by upregulating GPx1 and decreasing the cellular ROS level

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Patient population stratification: which patients will benefit most (frail older, endocrine decline, metabolic syndrome)