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PMIs physiological cardiovascular studies were limited to the demonstration that long-term IQOS aerosol exposure led to less aortic plaque than cigarette smoke in transgenic mice predisposed to atherosclerosis.44 In contrast, our direct evaluation of IQOS aerosols acute effects showed that brief exposures to IQOS aerosol from a single HeatStick caused rapid impairment of vascular endothelial function in rats comparable with that caused by cigarette smoke

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