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Some researchers consider this less physiological than the pulsatile pattern

4x Absorption Liposomal delivery boosts bioavailability and ensures targeted delivery

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Two different concentrations (10 and 20 mM) of each analgesic drug were used, which covered the reported therapeutic index and toxic concentration range of the drugs

Albeit larger studies are necessary to validate and strengthen the biomarker potential and the therapeutic benefits of targeting these pathways before translation into clinical practice is attainable