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For consumption, we used the midpoint of the reported number of cigarettes per dayfor example, three cigarettes per day if the category was one to five cigarettes per daywhich we then adjusted for carboxyhaemoglobin and cotinine because this allows for lower inhalation with increasing cigarette consumption as previously established.14 For studies that reported relative risks adjusted for age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categories

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