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This supports the conclusion that the embedded design did not introduce systematic bias

Consequently, even as overall participation rates decline, the intensity of consumption among remaining smokers often remains stable or increases, thereby offsetting volume losses with maintained or higher per unit profitability

Interventional Medicine and Applied Science 3:195202

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Idiopathic RAU occurs in 15%20% of the population beginning in the second decade of life and the disease generally becomes less severe over the age of 50