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Notably, the Na + -coordinating residues and the gating residues are separated by a helical break near G36 on TM1 and we speculate that Na + -binding may stabilise a conformation in which the extracellular gate can form

Animal studies show that IL-20 may cause kidney fibrosis, damage, and renal insufficiency by activating interstitial fibroblasts in the kidneys

was supported by the New National Excellence Program of the Ministry for Innovation and Technology (NKP-23-3-SZTE-535)

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