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After cleansing and toning, apply to face, leave on for 10-20 minutes

Cocaine binds with high affinity to the norepinephrine transporter (NET) on the presynaptic nerve terminal (Kd 0.3 M), acting as a transmembrane physical plug that inhibits reuptake of norepinephrine

Further randomized controlled trials are necessary to fully evaluate its efficacy in hyperpigmentation, TEWL, skin elasticity, and ultraviolet (UV) damage

doi: 10.3390/pathogens8030127, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 476

By reducing nicotinamide methylation, supports cellular NAD+ availabilitya critical coenzyme for mitochondrial function, energy metabolism, and cellular repair