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Regarding the implications of this study on legislations, following the final FDA rule in 2016 on the Family Smoking Prevention and Tobacco Control Act (FSPTCA) 70 , there was a need to improve water pipe (hookah) regulations

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This results in overclosure of the mandible (collapse of the jaws), [9] which extenuates the angular skin folds at the corners of the mouth, [14] in effect creating an intertriginous skin crease

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