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Although its a small amount of niacinamide, it caused me some redness in the nose area

MacEwan, TNF mediates the sustained activation of Nrf2 in human monocytes

Due to its vasodilatory action, nicotinic acid (niacin) should be used with caution in those patients with uncorrected hypotension (or predisposition to orthostatic hypotension), acute myocardial infarction, or unstable angina, particularly when vasodilator medications such as nitrates, calcium channel blockers, or adrenergic blocking agents are coadministered (see Drug Interactions)

Therefore, well-designed, large-scale randomized controlled trials are critically needed to assess ACs efficacy, safety, optimal dosage, and pharmacokinetics in human populations

Crit Reviews Immunol