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J Diabetes Sci Technol 14(6):10351064

The conversation around GLP-1 medications has grown fast over the past year (understatement!), and while much of the public dialogue has focused on women, men are very much part of it, too

GIP is the main incretin hormone in healthy people, causative of most the incretin effects, but the insulin response after GIP secretion in type 2 diabetes mellitus (T2DM) is strongly reduced

Most experienced researchers recommend dropping back to a lower escalation dose and working up gradually, even with prior GLP-1 agonist experience

The benefit is most pronounced for people who are still actively struggling with GI side effects or who are about to escalate to a higher dose