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That makes native IGF-I awkward as an experimental tool, because in any system containing serum or secreted IGFBPs the concentration a researcher adds is not the concentration the receptor sees

Substances frequently used as supplements to AAS include alcohol, amphetamine, caffeine, cannabinoids, clenbuterol, cocaine, codeine, creatine, ephedrine, erythropoietin, gamma hydroxybutyrate, GH, heroin, human chorionic gonadotropin, insulin, IGF-I, tamoxifen, tobacco, and many others (Ip et al., 2012, Sagoe, McVeigh, Bjornebekk et al., 2015, Borjesson, Garevik, Dahl et al., 2016)

GPx-4, glutathione peroxidase 4

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