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While there are some IUDs that do not contain hormones (such as copper IUDs), many IUDs contain the hormone progestin

Because prevention of OHE is a key clinical goal, close monitoring based on established OHE risk markers such as hypoalbuminemia and hyperammonemia represents a practical approach [144]

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It activates GLP-1R (class B GPCR) to stimulate Gs-cAMP-PKA signaling in pancreatic beta cells for glucose-dependent insulin secretion, suppress appetite through hypothalamic GLP-1R activation, and slow gastric emptying via vagal pathways