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IQOS heated tobacco devices use advanced technology to heat specially designed tobacco sticks at a lower temperature than cigarettes, avoiding combustion
While suppressed production of inflammatory mediators (IL-12 and IL-23) was attributed to reactive oxygen species or nicotine, stimulation with LPS or CD40 ligand resulted in up-regulation of certain inflammatory mediators (prostaglandin-E2, IL-8, and IL-10) [240,241,242]
Heat-generating parts that could cause injury to operators have protective devices
Over the years, the lawmakers have been amending the legislation, especially on the importation, packaging, selling, advertising, and the use of tobacco and nicotine-containing products, whether to be smoked or vaped
doi: 10.1007/s11469-021-00605-z 26
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