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Intracranial self-stimulation (ICSS) can also serve as an assessment of anhedonia or aversive state, in which rodents in an aversive state have been found to press a lever or spin a wheel to obtain higher levels of brain electrical self-stimulation (77, 78)

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Apart from epicanthal folds, additional midface/ocular signs were palpebral ptosis and sunken eyes (both 32%) and infraorbital creases (29.3%) (Fig

These include genetic factors, age, race, medical conditions, and unhealthy lifestyle choices