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Correlation of the Wnt signaling pathway with ASD pathophysiology has also been demonstrated by the finding that the Wnt pathway is regulated by chromodomain-helicase-DNA-binding protein 8 (CHD8), and de novo mutations of CHD8 are increasingly found in ASD individuals [183,184,185]

Glutathione levels in the body decline as we age

The effects observed may also be age specific and could be significantly different in mice of different ages