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Chillums can also be smoked horizontally like a regular pipe, so theyre a flexible option for those who are newer to smoking

Independent researchers who reviewed the study said that while e-cigarettes should not replace varenicline as a first-line treatment, they should be seen as a viable option for smokers trying to quit

However, as IVW can be sensitive to heterogeneity and horizontal pleiotropy, we performed additional sensitivity analyses using complementary MR methods, including MR-Egger regression, the weighted median method, and the weighted mode estimator, to evaluate the robustness of our findings and to account for potential violations of the MR assumptions

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