Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats
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If we consider the results by AR there were 6 values outside this interval, one in S, two in ExS, and three in NS, and the greatest differences corresponded to the prevalence of ExS and NS in Cantabria (2.4 and -2.7)
these may be related to specific sequence variants interfering with the action of the DNA methylation machinery ( in vitro studies suggest that the de novo methyltransferases DNMT3A and DNMT3B may have intrinsic preferences for certain flanking sequences (Jurkowska et al., 2011) and that the DNMT3A/DNMT3L complex favors methylation of CpGs distributed periodically and separated by distances of 810 bp ( DIP2B
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