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Thymosin Alpha-1 and Immune Fatigue "Immune fatigue" is the lay term for a very real phenomenon: the state of being neither acutely ill nor well, characterised by low-grade inflammation, poor recovery, and elevated susceptibility to secondary infections

[8] Contemporary reviews emphasize that first-generation agents such as diphenhydramine are inverse agonists rather than simple antagonists and note emerging data on gene-dose effects, transporter interactions, and tolerance development, all of which should temper prolonged off-label use for insomnia

Tran KL, Park YI, Pandya S, Muliyil NJ, Jensen BD, Huynh K, Nguyen QT