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You may notice early change after a few weeks, but the more meaningful result typically appears between 8 and 12 weeks, with continued improvement up to around 3 to 6 months

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PMID: 8053578 Twersky RS, Goel V, Narayan P, Weedon J (2014) The risk of hypertension after preoperative discontinuation of angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists in ambulatory and same-day admission patients

Cool compresses applied to affected areas can soothe irritation

[11] In my experience, you can have symptoms if your levels are below 700 pg/mL, and you may still benefit from a supplement