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Positive cell staining intensity is scored as follows: 0 (negative) 1 (mildly positive), 2 (moderately positive), 3 (extremely positive)

Patients were categorized into four treatment groups: (i) both SGLT2-I and GLP-1RA, (ii) SGLT2-I only, (iii) GLP-1RA only, and (iv) neither medication

However, the short stability of NR in circulation and rate-limited utilization by the expression of NRKs restrict its clinical application

Ditano-Vzquez P, Torres-Pea JD, Galeano-Valle F, Prez-Caballero AI, Demelo-Rodrguez P, Lopez-Miranda J et al (2019) The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil

GLP-1/glucagon) and triple agonists (GLP-1/GIP/glucagon) are already approved or in advanced clinical development for diabetes and obesity, with translational studies now extending to neurodegeneration