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Placental passage of metformin in women with polycystic ovary syndrome

Ponirakis G, et al

The decreased NADPH production results in insufficient reduction of oxidized glutathione disulfide (GSSG) and Prdx2, thus rendering the antioxidant system less effective ( Classes of Mutation and Spectrum of Deficiency G6PD deficiency is a heterogeneous condition with 217 mutations reported as of 2016

10.1186/1465-9921-7-10 133 MontgomeryM

And while the FDA hasnt explicitly published any reported interactions between these pound-shedding shots and birth control, the question of whether they may affect each other is a little more complicated