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doi:10.1093/ntr/ntab137

Tenderness and sensitivity may be present, although there is typically no severe pain

NRTs are popular among smokers aiming to quit due to their discreet usage, absence of smoke, and perceived lower harm compared to traditional tobacco products

The resulting comparison was between those who did not report any substance use initiation and a subgroup of 1,203 participants in the substance use initiation group who did not have any substance use experience when their MRIs were first captured

it likely reflects either a statistical artifact or residual confounding and should be interpreted with caution