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Table 4 Covariate-adjusted assessments of ANA associations with smoking status by time period

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I agree that fears about switching from cigarettes to e-cigarettes are overblown, and I roll my eyes in disbelief every time I hear a patient who has smoked for decades say that they fear the chemicals in e-cigarettes and vape products or that they made me sick. And on this point, as with smokeless and snus, e-cigarettes and newer heated tobacco products are more widely taken up by young people than by older individuals trying to stop smoking

This is partially consistent with this study, in which smokers exhibited an increase in activation of the striatum in response to smoking-related cues at baseline

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