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Regardless, based on previous findings of increased cytosolic Ca 2+ by nicotine, it is possible to hypothesize that such increases in [Ca 2+ ] i trigger mitochondrial Ca 2+ uptake, especially if with chronic nicotine exposure, mitochondrial localization toward the plasma membrane or the ER would allow for rapid uptake of Ca 2+ influx or intracellular release, respectively

There are also two FDA-approved non-nicotine-based therapies (both by Rx only): bupriopion (Zyban) and varenicline (Chantix)

Men 65 or older who smoke are twice as likely to die from a stroke, and women smokers are about one and a half times as likely to die from a stroke than their nonsmoking counterparts

This should not be surprising: tobacco is extremely bad for health

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