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The trilayered patch formulations enabled rapid initial drug release especially for nicotine base in 30 min and fast-to-slow permeation rates (66)
Mesenchymal stem cells (MSCs) have also been employed for the treatment of ARDS, with multiple clinical trials (NCT01902082, NCT01775774, NCT02097641) having validated the safety of MSC use and demonstrated improvements in ARDS-related inflammation (Zheng et al., 2014) and respiratory dysfunction (Matthay et al., 2019b) to a certain extent
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