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Dosage inaccuracies of up to 29% and 39% have been reported, which can lead to ineffective treatment or potential overdose

On the other hand, the balance between Bax and Bcl-2 expression was altered by the downregulation of HSP70 and the absence of its protective effect on the cell defense system

This provides novel insight into the remarkably different metabolic control mechanism and venom function in monotremes and an unique example of how different selective pressures act upon a single gene in the absence of gene duplication

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