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Redox-active small molecules (Methylene Blue): investigated for mitochondrial electron-transport-chain interaction and cellular oxidative-stress models

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These studies reported trends toward increased numbers of mature oocytes, higher-quality embryos, and improved clinical pregnancy rates, though many of these improvements didn't reach statistical significance due to small sample sizes. A recent review concluded that antioxidant therapies including melatonin show promise for improving ART outcomes, but we still need larger trials before firm recommendations can be made. Melatonin is generally well-tolerated, though it may make you drowsy

Maudoux A, Lefebvre P, Cabay J-E, et al

The aim is to isolate or enhance beneficial properties like neuroimmune modulation and plasticity while minimizing the hallucinogenic effects