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Several questions remain unanswered, including the association between irAEs onset and the type of organ system toxicities, toxicity grading, ITBs, confounding comorbidities like autoimmune diseases, immune heterogeneity and patient intrinsic factors

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Indeed, every organ of the body maintains its own GSH concentrations based on their metabolic activity, generation of ROS and cellular needs

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Since lipomas appear to occur in some breeds more than others, at least some genetic link is likely responsible for lipomas in dogs

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Jul 9 2019;10(7)doi:10.3390/genes10070518

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