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Our data not only unveils a previously unknown pathway of ERMCS-localised GPCR signalling into mitochondria, potentially applicable to other GPCRs beyond the GLP-1R, but also opens the door to further roles of the GLP-1R in the regulation of mitochondrial lipid metabolism, a process tightly linked to changes in mitochondrial morphology governed by MICOS complex activity 10

The discovery of vitamin B12 in the 1940s allowed veganism to become a realistic lifestyle

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Mild nausea, constipation, or fatigue are common early on