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However, naturally produced GLP-1 has a very short half-lifeapproximately 2 to 3 minutesbecause it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

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However, when semaglutide is combined with insulin therapy or insulin-stimulating diabetes medications like sulfonylureas, the additive effect can push blood glucose too low, creating hypoglycemic episodes