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Implanting gut microbiota from aged 3xTg AD mice (APP Swedish, MAPT P301L, and PSEN1 M146V) to young 3xTg mice increased intestinal permeability and temporally augmented C/EBP/AEP activation ( FIGURE 3 The peripheral etiology of neurodegenerative disorders links the role of gut microbiota in influencing T-cell differentiation and autoimmune regulation