1,4 Hyperglycemia, dyslipidemia, and insulin resistance activate various metabolic pathways, resulting in oxidative stress, mitochondrial dysfunction, inflammation, and microvascular damage, culminating in neuronal injury, Schwann cell damage, and myelin sheath degeneration
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Purging is a normal cellular turnover event
However, the weight loss induced by GLP-1R mono-therapies in obese T2DM patients is modest indicating a need for more robust therapeutic options