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Importantly, the QMP substitutions did not affect the ability of GLP-1 to activate the GLP-1R

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these were the most frequently reported AEs across all treatment arms but they were mostly transient and mild/moderate in severity, consistent with the safety profile of the GLP-1RA drug class [8, 18, 24]

8 Approximately 60% of patients with acute cholecystitis are female, but the illness is generally more severe in males

These broadened prescribing criteria for Ozempic mean that more people will experience severe side effects from the drug