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On the other hand, eosinophil airway inflammation has been proposed as a determinant of breathlessness [4143] via mechanisms affecting either the mechanical pathways that control breathlessness [44, 45] or the afferent nerves involved in perception of dyspnea [16, 41]

Cigarette smoking has been known to increase susceptibility to infection likely from dysregulation of immune function [2], but the precise underlying molecular mechanisms remain unclear

The court also heard from Samantha McMillen, Depps stylist of around 18 years, who appeared via video-link