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Because no single biomarker is available that can be used alone to predict the reduction in harm from smoking (ventilated vs nonventilated cigarettes), a panel of biomarkers of exposure to carcinogens and lung toxicants, markers of oxidative damage and inflammation should be measured in lung, blood, or/and urine

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These also have a strong correlation with smoking, but, of note, adenocarcinoma is the most common type of lung cancer found in people who dont smoke