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They also had concentrations of a specific carcinogen at levels comparable with cigarette smokers

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Leveraging these technological advances, recent multi-omics investigations have delineated smoking-induced remodeling of respiratory microbiota, with these dysbiotic changes further correlating to heightened risks of diverse respiratory pathologies (Table 2)

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Also for many traditional smokers, cigarette smoking becomes part of their daily routine & proves to be an extremely difficult habit to change quickly