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Diet, nutrition, physical activity and cancer: a global perspective a summary of the Third Expert Report

Genetic Factors and Bloating Sensitivity Recent genetic research suggests that variations in genes controlling appetite regulation and GI motilitysuch as GLP1R (rs6923761) and GIPR (rs1800437)may influence how intensely individuals experience bloating and other digestive side effects

Glucagon Suppression: They lower the amount of glucagon (a hormone that raises blood sugar) the liver produces

First, some of the muscle change happens with any rapid weight loss, and a portion may be a normal adjustment to a smaller body rather than harmful wasting (Mocciaro and colleagues, BMJ Nutrition Prevention and Health , 2025)

Neuroradiol J (2016) 29:219