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Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts

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The earliest UK private access via online pharmacies is likely in 2027 or 2028, with NHS access following a NICE appraisal

It works by targeting two hormone pathways involved in appetite control and blood sugar regulation, which can lead to stronger reductions in hunger, fewer cravings, and improved portion control for many patients

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