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GLP-1s mimic natural hormones involved in appetite and glucose regulation, while older medications tend to rely on central nervous system stimulation (like phentermine and Qsymia) or digestive fat-blocking (as with orlistat)

In a randomized, controlled clinical study (Study E) (n=570), another insulin glargine product, 100 units/mL, was evaluated for 52 weeks in combination with oral anti-diabetic medications (a sulfonylurea, metformin, acarbose, or combination of these drugs)