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Heres some information to help you and your healthcare provider make responsible decisions for your long-term health: Who should avoid GLP-1 medications GLP-1 medications like semaglutide and liraglutide may not be right for you if any of the following conditions apply: You are allergic or hypersensitive to GLP-1 receptor agonists You are pregnant or planning to become pregnant You have severe gastroparesis or inflammatory bowel disease You have a personal or family history of specific thyroid conditions, including multiple endocrine neoplasia (2A or 2B) or medullary thyroid cancer , You have had pancreatitis or develop it while on these drugs You are taking other semaglutide medications Boxed Warning : Risk of Thyroid C-Cell Tumors GLP-1 medications have been linked to a risk of thyroid C-cell tumors based on animal studies

Persistent stimulation of these receptors amplifies pro-inflammatory signaling, promoting macrophage and T cell recruitment and sustaining hepatic inflammation (138)

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Male: Potential benefit for varicocele-related damage and testicular inflammation

Aliment Pharmacol Ther 58:11511162