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Using male C57BL/6 mice, the authors evaluated the effects of Ex4 (2.4 g/kg, i.p.) on morphine-induced CPP, locomotor sensitization, and analgesic tolerance

Common returning side effects include nausea (often the most prominent), changes in bowel habits (constipation or diarrhea), reduced appetite that might feel more dramatic than you remember, fatigue during the first few weeks, and occasional headaches

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however, treatment usually starts at a lower dose that slowly increases over time to help the body adjust and reduce side effects, as explained in detail by medical professionals