A 1994 in vivo study by Natera, Jiang, and Ng extended the observation into a whole animal, reporting that chronic administration of synthetic hGH 177 to 191 to genetically obese (ob/ob) mice was associated with reduced cumulative body-weight gain and reduced adipose mass relative to controls [2]
When NNMT is inhibited: NAD+ levels rise Mitochondria become more efficient Cells burn more energy, even at rest This effect helps the body shift into a more metabolically active state, making it easier to reduce fat and preserve muscle during weight loss
Blocking NNMT can boost NAD productionenhancing cellular energy, improving mitochondrial function, and accelerating the breakdown of fat
The result isn't dramatic collapse it's a slow, persistent drag on your energy that's easy to blame on sleep, stress, or aging
When undergoing testosterone replacement therapy (TRT), many patients incorporate human chorionic gonadotropin (HCG) into their regimen