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The higher fatty acid synthesis in CKD may also induce NLRP3 pathway activation by the fatty acid synthase (FASN) induction, an enzyme that is upregulated in pro-inflammatory macrophages type I, leading to upregulation of the expression of the inflammasome components: NLRP3, caspase 1 and pro-IL-1 (Olona et al

Selenophosphate synthetase 2 is the selenoenzyme that catalyzes the ATP-dependent synthesis of selenophosphate from hydrogen selenide ( Figure 4 ) (5)

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