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Stay at the lowest effective dose if 1mg achieves clinical targets, there is no cost reason to titrate to 2mg

Patients experiencing persistent vomiting or diarrhea should be monitored for signs of dehydration and renal dysfunction, with appropriate fluid replacement and potentially temporary discontinuation of the medication if necessary

Subject characteristics per treatment group in the two trials are shown in Supplementary Tables S2 and S3, respectively

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If labs are needed, your clinician will explain what to obtain and how to follow up