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However, AGEs were found to both stimulate (202) and inhibit (203) APC maturation

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doi: 10.1016/j.jhazmat.2021.126707 63 TichoALMalhotraPDudejaPKGillRKAlrefaiWA

V1 the volume of perchloric acid standard solution consumed in titrating the sample solution, in milliliters (mL)

The reason is likely biological: sebaceous gland activity declines naturally with age, and the hormonal triggers that drive relapse in younger patients are less volatile (with the exception of active perimenopause or TRT use)